Oxidised metabolites of the omega-6 fatty acid linoleic acid activate dFOXO
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چکیده
منابع مشابه
Protective Effects of Linoleic Acid against the Cytotoxicity of Palmitic Fatty Acid in Rat Cardiomyocytes
Background & Aims: Lipotoxicity is the process through which accumulation of lipid intermadiates leads to cellular dysfunction. The worldwide prevalence of cardiovascular diseases has been increased dramatically due to lipotoxicity. According to the peformed studies, saturated and unsaturated fatty acids differ significantly in their contributions to lipotoxicity. It has been r...
متن کاملThe omega-6/omega-3 fatty acid ratio: health implications
The Center for Genetics, Nutrition and Health, 2001 S Street, NW, Suite 530, Washington DC 20009 USA Abstract: Today, Western diets are characterized by a higher omega-6 and a lower omega-3 fatty acid intake, whereas during the Paleolithic period when human’s genetic profile was established, there was a balance between omega-6 and omega-3 fatty acids. Their balance is an...
متن کاملGamma linolenic acid: an antiinflammatory omega-6 fatty acid.
Inflammation plays an important role in health and disease. Most of the chronic diseases of modern society, including cancer, diabetes, heart disease, arthritis, Alzheimer's disease, etc. have inflammatory component. At the same time, the link between diet and disease is also being recognized. Amongst dietary constituents, fat has gained most recognition in affecting health. Saturated and trans...
متن کاملConversion of eicosapentaenoic acid to chain-shortened omega-3 fatty acid metabolites by peroxisomal oxidation.
Human skin fibroblasts can convert arachidonic acid to 14- and 16-carbon polyunsaturated fatty acid products by peroxisomal beta-oxidation. The purpose of this study was to determine whether similar products are formed from eicosapentaenoic acid (EPA) and whether EPA and arachidonic acid compete for utilization by this oxidative pathway. Three radiolabeled metabolites with shorter retention tim...
متن کاملOmega-3 fatty acid supplementation
Free fatty acids and the risk of sudden death • Elevated circulating free fatty acids have been reported to be a risk factor for sudden death. In the Paris Prospective Study reported by Jouven et al. [ 3 ], 5250 men were observed over a mean follow-up period of 22 years. The concept that omega-3 (n-3) polyunsaturated fatty acids (PUFAs) may have potential health benefits has been supported by e...
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ژورنال
عنوان ژورنال: Life Science Alliance
سال: 2020
ISSN: 2575-1077
DOI: 10.26508/lsa.201900356